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Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis

The NHLBI GRADS program has gathered a team of investigators with different backgrounds to conduct state-of-the-art studies of two serious and understudied conditions that affect the lungs. This collaborative effort brings together clinicians with expertise in lung diseases and scientists who study microbes, DNA, and computer science.

The researchers hope to discover links in both directions between the microbes in the lung and these lung diseases. How do AATD and Sarcoidosis affect the microbial environment in the lung? And how do the microbes change how AATD and Sarcoidosis progress and how severe the disease becomes?

GRADS has nine Clinical Centers and one central Genomics and Informatics Center. Together, the GRADS Clinical Centers are enrolling a group of approximately 200 AATD and approximately 400 Sarcoidosis research participants.


The program is funded by the National Institutes of Health, National Heart, Lung and Blood Institute.


Enrollment at all of the GRADS Clinical Centers is now closed. Thank you for your interest in the study.

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Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis